The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors

Chemo-resistance in acute myeloid leukemia (AML) patients is driven by leukemic stem cells (LSCs) resulting in high rates of relapse and low overall survival. Here, we demonstrate that upregulation of the splicing factor, RBM17 preferentially marks and sustains LSCs and directly correlates with shor...

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Detalles Bibliográficos
Autores principales: Liu, Lina, Vujovic, Ana, Deshpande, Nandan P., Sathe, Shashank, Anande, Govardhan, Chen, He Tian Tony, Xu, Joshua, Minden, Mark D., Yeo, Gene W., Unnikrishnan, Ashwin, Hope, Kristin J., Lu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250932/
https://www.ncbi.nlm.nih.gov/pubmed/35781533
http://dx.doi.org/10.1038/s41467-022-31155-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250932/
https://www.ncbi.nlm.nih.gov/pubmed/35781533
http://dx.doi.org/10.1038/s41467-022-31155-0

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