Recent Advances in Cancer Drug Discovery Through the Use of Phenotypic Reporter Systems, Connectivity Mapping, and Pooled CRISPR Screening

Multi-omic approaches offer an unprecedented overview of the development, plasticity, and resistance of cancer. However, the translation from anti-cancer compounds identified in vitro to clinically active drugs have a notoriously low success rate. Here, we review how technical advances in cell cultu...

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Detalles Bibliográficos
Autores principales: Salame, Natasha, Fooks, Katharine, El-Hachem, Nehme, Bikorimana, Jean-Pierre, Mercier, François E., Rafei, Moutih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250974/
https://www.ncbi.nlm.nih.gov/pubmed/35795568
http://dx.doi.org/10.3389/fphar.2022.852143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250974/
https://www.ncbi.nlm.nih.gov/pubmed/35795568
http://dx.doi.org/10.3389/fphar.2022.852143

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