Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein

Pharmacokinetic/pharmacodynamic (PK/PD) modeling was performed to quantitatively integrate preclinical pharmacology and toxicology data for determining the therapeutic index (TI) of an interleukin-10 (IL-10) fragment crystallizable (Fc) fusion protein. Mouse Fc fused with mouse IL-10 (mFc-mIL-10) wa...

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Detalles Bibliográficos
Autores principales: Yang, Zheng, Loy, James, Poirson, Brian, Dai, Yanshan, Rajendran, Surendran, Xu, Shihua, Spires, Vanessa, Gururajan, Murali, Lin, Zheng, Arbanas, Jaren, Carl, Stephen, Pace, Samantha, Wang, Yun, Mehl, John, Vasudevan, Krishna, Spires, Thomas, Novosiadly, Ruslan, Coker, Shodeinde, Perez, Raymond, Covello, Kelly, Morin, Paul, Graziano, Robert, Broz, Miranda, Lehman-McKeeman, Lois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251408/
https://www.ncbi.nlm.nih.gov/pubmed/35795558
http://dx.doi.org/10.3389/fphar.2022.829063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251408/
https://www.ncbi.nlm.nih.gov/pubmed/35795558
http://dx.doi.org/10.3389/fphar.2022.829063

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