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Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein
Pharmacokinetic/pharmacodynamic (PK/PD) modeling was performed to quantitatively integrate preclinical pharmacology and toxicology data for determining the therapeutic index (TI) of an interleukin-10 (IL-10) fragment crystallizable (Fc) fusion protein. Mouse Fc fused with mouse IL-10 (mFc-mIL-10) wa...
Autores principales: | Yang, Zheng, Loy, James, Poirson, Brian, Dai, Yanshan, Rajendran, Surendran, Xu, Shihua, Spires, Vanessa, Gururajan, Murali, Lin, Zheng, Arbanas, Jaren, Carl, Stephen, Pace, Samantha, Wang, Yun, Mehl, John, Vasudevan, Krishna, Spires, Thomas, Novosiadly, Ruslan, Coker, Shodeinde, Perez, Raymond, Covello, Kelly, Morin, Paul, Graziano, Robert, Broz, Miranda, Lehman-McKeeman, Lois |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251408/ https://www.ncbi.nlm.nih.gov/pubmed/35795558 http://dx.doi.org/10.3389/fphar.2022.829063 |
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