Single-Dose Intra-Cartilage Delivery of Kartogenin Using a Cationic Multi-Arm Avidin Nanocarrier Suppresses Cytokine-Induced Osteoarthritis-Related Catabolism

OBJECTIVE: Kartogenin (KGN) has proven as a both chondrogenic and chondroprotective drug for osteoarthritis (OA) therapy. However, being a small hydrophobic molecule, KGN suffers from rapid joint clearance and inability to penetrate cartilage to reach chondrocytes following intra-articular administr...

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Detalles Bibliográficos
Autores principales: He, Tengfei, Shaw, Irfhan, Vedadghavami, Armin, Bajpayee, Ambika G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251829/
https://www.ncbi.nlm.nih.gov/pubmed/35491681
http://dx.doi.org/10.1177/19476035221093072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251829/
https://www.ncbi.nlm.nih.gov/pubmed/35491681
http://dx.doi.org/10.1177/19476035221093072

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