Temperature-responsive optogenetic probes of cell signaling

We describe single-component optogenetic probes whose activation dynamics depend on both light and temperature. We used the BcLOV4 photoreceptor to stimulate Ras and PI3K signaling in mammalian cells, allowing activation over a large dynamic range with low basal levels. Surprisingly, we found that B...

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Detalles Bibliográficos
Autores principales: Benman, William, Berlew, Erin E., Deng, Hao, Parker, Caitlyn, Kuznetsov, Ivan A., Lim, Bomyi, Siekmann, Arndt F., Chow, Brian Y., Bugaj, Lukasz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252025/
https://www.ncbi.nlm.nih.gov/pubmed/34937907
http://dx.doi.org/10.1038/s41589-021-00917-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252025/
https://www.ncbi.nlm.nih.gov/pubmed/34937907
http://dx.doi.org/10.1038/s41589-021-00917-0

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