CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

Immunotherapies targeting the “don’t eat me” myeloid checkpoint constituted by CD47 SIRPα interaction have promising clinical potential but are limited by toxicities associated with the destruction of non-tumor cells. These dose-limiting toxicities demonstrate the need to highlight the mechanisms of...

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Detalles Bibliográficos
Autores principales: Gondois-Rey, Françoise, Miller, Thomas, Laletin, Vladimir, Morelli, Xavier, Collette, Yves, Nunès, Jacques, Olive, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252436/
https://www.ncbi.nlm.nih.gov/pubmed/35795660
http://dx.doi.org/10.3389/fimmu.2022.899068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252436/
https://www.ncbi.nlm.nih.gov/pubmed/35795660
http://dx.doi.org/10.3389/fimmu.2022.899068

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