DEMO2: Assemble multi-domain protein structures by coupling analogous template alignments with deep-learning inter-domain restraint prediction

Most proteins in nature contain multiple folding units (or domains). The revolutionary success of AlphaFold2 in single-domain structure prediction showed potential to extend deep-learning techniques for multi-domain structure modeling. This work presents a significantly improved method, DEMO2, which...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaogen, Peng, Chunxiang, Zheng, Wei, Li, Yang, Zhang, Guijun, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Web Server Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252800/
https://www.ncbi.nlm.nih.gov/pubmed/35536281
http://dx.doi.org/10.1093/nar/gkac340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252800/
https://www.ncbi.nlm.nih.gov/pubmed/35536281
http://dx.doi.org/10.1093/nar/gkac340

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