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Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype
BACKGROUND: Genes involved in epigenetic regulation are central for chromatin structure and gene expression. Specific mutations in these might promote carcinogenesis in several tissue types. METHODS: We used exome, whole-genome and Sanger sequencing to detect rare variants shared by seven affected i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252859/ https://www.ncbi.nlm.nih.gov/pubmed/34281993 http://dx.doi.org/10.1136/jmedgenet-2021-107747 |