Cargando…

Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway

Repeated morphine administration induces tolerance to its analgesic effects. A previous study reported that repeated morphine treatment activates transient receptor potential vanilloid type 1 (TRPV1) expression in the sciatic nerve, dorsal root ganglion, and spinal cord, contributing to morphine tol...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Thi-Lien, Nam, Yun-Son, Lee, Seok-Yong, Jang, Choon-Gon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252876/
https://www.ncbi.nlm.nih.gov/pubmed/35616070
http://dx.doi.org/10.4062/biomolther.2022.014
_version_ 1784740371051315200
author Nguyen, Thi-Lien
Nam, Yun-Son
Lee, Seok-Yong
Jang, Choon-Gon
author_facet Nguyen, Thi-Lien
Nam, Yun-Son
Lee, Seok-Yong
Jang, Choon-Gon
author_sort Nguyen, Thi-Lien
collection PubMed
description Repeated morphine administration induces tolerance to its analgesic effects. A previous study reported that repeated morphine treatment activates transient receptor potential vanilloid type 1 (TRPV1) expression in the sciatic nerve, dorsal root ganglion, and spinal cord, contributing to morphine tolerance. In the present study, we analyzed TRPV1 expression and binding sites in supraspinal pain pathways in morphine-tolerant mice. The TRPV1 mRNA levels and binding sites were remarkably increased in the cortex and thalamus of these animals. Our data provide additional insights into the effects of morphine on TRPV1 in the brain and suggest that changes in the expression of, and binding to TRPV1 in the brain are involved in morphine tolerance.
format Online
Article
Text
id pubmed-9252876
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Korean Society of Applied Pharmacology
record_format MEDLINE/PubMed
spelling pubmed-92528762022-07-12 Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway Nguyen, Thi-Lien Nam, Yun-Son Lee, Seok-Yong Jang, Choon-Gon Biomol Ther (Seoul) Original Article Repeated morphine administration induces tolerance to its analgesic effects. A previous study reported that repeated morphine treatment activates transient receptor potential vanilloid type 1 (TRPV1) expression in the sciatic nerve, dorsal root ganglion, and spinal cord, contributing to morphine tolerance. In the present study, we analyzed TRPV1 expression and binding sites in supraspinal pain pathways in morphine-tolerant mice. The TRPV1 mRNA levels and binding sites were remarkably increased in the cortex and thalamus of these animals. Our data provide additional insights into the effects of morphine on TRPV1 in the brain and suggest that changes in the expression of, and binding to TRPV1 in the brain are involved in morphine tolerance. The Korean Society of Applied Pharmacology 2022-07-01 2022-05-26 /pmc/articles/PMC9252876/ /pubmed/35616070 http://dx.doi.org/10.4062/biomolther.2022.014 Text en Copyright © 2022, The Korean Society of Applied Pharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nguyen, Thi-Lien
Nam, Yun-Son
Lee, Seok-Yong
Jang, Choon-Gon
Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway
title Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway
title_full Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway
title_fullStr Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway
title_full_unstemmed Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway
title_short Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway
title_sort repeated morphine administration increases trpv1 mrna expression and autoradiographic binding at supraspinal sites in the pain pathway
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252876/
https://www.ncbi.nlm.nih.gov/pubmed/35616070
http://dx.doi.org/10.4062/biomolther.2022.014
work_keys_str_mv AT nguyenthilien repeatedmorphineadministrationincreasestrpv1mrnaexpressionandautoradiographicbindingatsupraspinalsitesinthepainpathway
AT namyunson repeatedmorphineadministrationincreasestrpv1mrnaexpressionandautoradiographicbindingatsupraspinalsitesinthepainpathway
AT leeseokyong repeatedmorphineadministrationincreasestrpv1mrnaexpressionandautoradiographicbindingatsupraspinalsitesinthepainpathway
AT jangchoongon repeatedmorphineadministrationincreasestrpv1mrnaexpressionandautoradiographicbindingatsupraspinalsitesinthepainpathway