Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations

Maintenance therapy (MT) with oral methotrexate (MTX) and 6-mercaptopurine (6-MP) is essential for the cure of acute lymphoblastic leukemia (ALL). MTX and 6-MP interfere with nucleotide synthesis and salvage pathways. The primary cytotoxic mechanism involves the incorporation of thioguanine nucleoti...

Descripción completa

Detalles Bibliográficos
Autores principales: Toksvang, Linea N., Lee, Shawn H. R., Yang, Jun J., Schmiegelow, Kjeld
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252897/
https://www.ncbi.nlm.nih.gov/pubmed/35654820
http://dx.doi.org/10.1038/s41375-022-01591-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252897/
https://www.ncbi.nlm.nih.gov/pubmed/35654820
http://dx.doi.org/10.1038/s41375-022-01591-4

Ejemplares similares