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Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations

Maintenance therapy (MT) with oral methotrexate (MTX) and 6-mercaptopurine (6-MP) is essential for the cure of acute lymphoblastic leukemia (ALL). MTX and 6-MP interfere with nucleotide synthesis and salvage pathways. The primary cytotoxic mechanism involves the incorporation of thioguanine nucleoti...

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Detalles Bibliográficos
Autores principales:	Toksvang, Linea N., Lee, Shawn H. R., Yang, Jun J., Schmiegelow, Kjeld
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252897/ https://www.ncbi.nlm.nih.gov/pubmed/35654820 http://dx.doi.org/10.1038/s41375-022-01591-4

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