Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms

Mutations of the JAK2 gene are frequent aberrations in the aging hematopoietic system and in myeloid neoplasms. While JAK-inhibitors efficiently reduce hyperinflammation induced by the constitutively active mutated JAK2 kinase, the malignant clone and abundance of mutated cells remains rather unaffe...

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Detalles Bibliográficos
Autores principales: Ernst, Philipp, Schnöder, Tina M., Huber, Nicolas, Perner, Florian, Jayavelu, Ashok Kumar, Eifert, Theresa, Hsu, Chen-Jen, Tubío-Santamaría, Nuria, Crodel, Carl C., Ungelenk, Martin, Hübner, Christian A., Clement, Joachim H., Hochhaus, Andreas, Heidel, Florian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252905/
https://www.ncbi.nlm.nih.gov/pubmed/35654819
http://dx.doi.org/10.1038/s41375-022-01611-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252905/
https://www.ncbi.nlm.nih.gov/pubmed/35654819
http://dx.doi.org/10.1038/s41375-022-01611-3

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