Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block its activity and suppress T cell activation. Here, we report structures of human Kv1.3 alone, with a n...

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Detalles Bibliográficos
Autores principales: Selvakumar, Purushotham, Fernández-Mariño, Ana I., Khanra, Nandish, He, Changhao, Paquette, Alice J., Wang, Bing, Huang, Ruiqi, Smider, Vaughn V., Rice, William J., Swartz, Kenton J., Meyerson, Joel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253088/
https://www.ncbi.nlm.nih.gov/pubmed/35788586
http://dx.doi.org/10.1038/s41467-022-31285-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253088/
https://www.ncbi.nlm.nih.gov/pubmed/35788586
http://dx.doi.org/10.1038/s41467-022-31285-5

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