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Structures and gating mechanisms of human bestrophin anion channels
Bestrophin-1 (Best1) and bestrophin-2 (Best2) are two members of the bestrophin family of calcium (Ca(2+))-activated chloride (Cl(−)) channels with critical involvement in ocular physiology and direct pathological relevance. Here, we report cryo-EM structures of wild-type human Best1 and Best2 in va...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253114/ https://www.ncbi.nlm.nih.gov/pubmed/35789156 http://dx.doi.org/10.1038/s41467-022-31437-7 |