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Structures and gating mechanisms of human bestrophin anion channels

Bestrophin-1 (Best1) and bestrophin-2 (Best2) are two members of the bestrophin family of calcium (Ca(2+))-activated chloride (Cl(−)) channels with critical involvement in ocular physiology and direct pathological relevance. Here, we report cryo-EM structures of wild-type human Best1 and Best2 in va...

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Detalles Bibliográficos
Autores principales:	Owji, Aaron P., Wang, Jiali, Kittredge, Alec, Clark, Zada, Zhang, Yu, Hendrickson, Wayne A., Yang, Tingting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253114/ https://www.ncbi.nlm.nih.gov/pubmed/35789156 http://dx.doi.org/10.1038/s41467-022-31437-7

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