Benzylamines as highly potent inhibitors of the sterol biosynthesis pathway in Leishmania amazonensis leading to oxidative stress and ultrastructural alterations

Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds selectively designed to inhibit the squalene synthase (SQS) that catalyzes the first committed reaction on the sterol biosynthesis pathway. Herein, we studied seven new b...

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Detalles Bibliográficos
Autores principales: de Macedo-Silva, Sara Teixeira, Visbal, Gonzalo, Souza, Gabrielle Frizzo, dos Santos, Mayara Roncaglia, Cämmerer, Simon B., de Souza, Wanderley, Rodrigues, Juliany Cola Fernandes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253131/
https://www.ncbi.nlm.nih.gov/pubmed/35788652
http://dx.doi.org/10.1038/s41598-022-15449-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253131/
https://www.ncbi.nlm.nih.gov/pubmed/35788652
http://dx.doi.org/10.1038/s41598-022-15449-3

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