Benzylamines as highly potent inhibitors of the sterol biosynthesis pathway in Leishmania amazonensis leading to oxidative stress and ultrastructural alterations

Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds selectively designed to inhibit the squalene synthase (SQS) that catalyzes the first committed reaction on the sterol biosynthesis pathway. Herein, we studied seven new b...

Descripción completa

Detalles Bibliográficos
Autores principales: de Macedo-Silva, Sara Teixeira, Visbal, Gonzalo, Souza, Gabrielle Frizzo, dos Santos, Mayara Roncaglia, Cämmerer, Simon B., de Souza, Wanderley, Rodrigues, Juliany Cola Fernandes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253131/
https://www.ncbi.nlm.nih.gov/pubmed/35788652
http://dx.doi.org/10.1038/s41598-022-15449-3

Ejemplares similares

Ejemplares similares