Neutralization of ionic interactions by dextran-based single-chain nanoparticles improves tobramycin diffusion into a mature biofilm

The extracellular matrix protects biofilm cells by reducing diffusion of antimicrobials. Tobramycin is an antibiotic used extensively to treat P. aeruginosa biofilms, but it is sequestered in the biofilm periphery by the extracellular negative charge matrix and loses its efficacy significantly. Disp...

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Detalles Bibliográficos
Autores principales: Blanco-Cabra, Núria, Movellan, Julie, Marradi, Marco, Gracia, Raquel, Salvador, Cristian, Dupin, Damien, Loinaz, Iraida, Torrents, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253323/
https://www.ncbi.nlm.nih.gov/pubmed/35787627
http://dx.doi.org/10.1038/s41522-022-00317-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253323/
https://www.ncbi.nlm.nih.gov/pubmed/35787627
http://dx.doi.org/10.1038/s41522-022-00317-9

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