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Sesamin protects against neurotoxicity via inhibition of microglial activation under high glucose circumstances through modulating p38 and JNK signaling pathways

Diabetes mellitus (DM), one of the principal causes of morbidity and mortality worldwide, is implicated in the progression of age-related neurodegenerative diseases (NDDs), in which microglial activation is a crucial mediator. Sesamin, a kind of phytochemical, shows inhibitory effects on microglial...

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Detalles Bibliográficos
Autores principales: Kongtawelert, Prachya, Kaewmool, Chayanut, Phitak, Thanyaluck, Phimphilai, Mattabhorn, Pothacharoen, Peraphan, Shwe, Thuzar Hla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253356/
https://www.ncbi.nlm.nih.gov/pubmed/35788665
http://dx.doi.org/10.1038/s41598-022-15411-3