Increasing stiffness promotes pulmonary retention of ligand-directed dexamethasone-loaded nanoparticle for enhanced acute lung inflammation therapy

Inhaled nanoparticles (NPs) need to penetrate the bronchial mucosa to deliver drug payloads deeply in the lung for amplified local therapy. However, the bronchial mucociliary barrier eliminates NPs rapidly, which considerably limits their mucosal penetration. In this study, we find that surface liga...

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Detalles Bibliográficos
Autores principales: Yu, Yinglan, Li, Shujie, Yao, Yuan, Shen, Xinran, Li, Lian, Huang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253482/
https://www.ncbi.nlm.nih.gov/pubmed/35846844
http://dx.doi.org/10.1016/j.bioactmat.2022.06.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253482/
https://www.ncbi.nlm.nih.gov/pubmed/35846844
http://dx.doi.org/10.1016/j.bioactmat.2022.06.016

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