Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism

Proteolytic cleavage is an important post-translational mechanism to increase protein variability and functionality. In cancer, this process can be deregulated to shut off tumor-suppressive functions. Here, we report that in glioblastoma (GBM), the tumor suppressor ZBTB18 is targeted for protein cle...

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Detalles Bibliográficos
Autores principales: Masilamani, Anie P., Schulzki, Rana, Yuan, Shuai, Haase, Ira V., Kling, Eva, Dewes, Franziska, Andrieux, Geoffroy, Börries, Melanie, Schnell, Oliver, Heiland, Dieter H., Schilling, Oliver, Ferrarese, Roberto, Carro, Maria S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253709/
https://www.ncbi.nlm.nih.gov/pubmed/35800763
http://dx.doi.org/10.1016/j.isci.2022.104625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253709/
https://www.ncbi.nlm.nih.gov/pubmed/35800763
http://dx.doi.org/10.1016/j.isci.2022.104625

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