Cargando…

Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis

Bone marrow mesenchymal stromal cells (MSCs) have immunomodulatory and regenerative potential. However, culture conditions govern their metabolic processes and therapeutic efficacy. Here we show that culturing donor-derived MSCs in Plasmax™, a physiological medium with the concentrations of nutrient...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taurino, Giuseppe, Deshmukh, Ruhi, Villar, Victor H., Chiu, Martina, Shaw, Robin, Hedley, Ann, Shokry, Engy, Sumpton, David, Dander, Erica, D'Amico, Giovanna, Bussolati, Ovidio, Tardito, Saverio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254159/ https://www.ncbi.nlm.nih.gov/pubmed/35752287 http://dx.doi.org/10.1016/j.molmet.2022.101532

Ejemplares similares

Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth
por: Chiu, Martina, et al.
Publicado: (2018)

ALL blasts drive primary mesenchymal stromal cells to increase asparagine availability during asparaginase treatment
por: Chiu, Martina, et al.
Publicado: (2021)

Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells
por: Chiu, Martina, et al.
Publicado: (2020)

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
por: Rattigan, Kevin M., et al.
Publicado: (2023)

The Role of Amino Acids in the Crosstalk Between Mesenchymal Stromal Cells and Neoplastic Cells in the Hematopoietic Niche
por: Chiu, Martina, et al.
Publicado: (2021)

Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis
por: Li, Chun-Yuan, et al.
Publicado: (2016)

Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis
por: Shen, Jun, et al.
Publicado: (2021)

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma
por: Khurshed, Mohammed, et al.
Publicado: (2017)

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia
por: Chiu, Martina, et al.
Publicado: (2020)

Mesenchymal Stromal Cells (MSCs): An Ally of B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells in Disease Maintenance and Progression within the Bone Marrow Hematopoietic Niche
por: Fallati, Alessandra, et al.
Publicado: (2022)

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
por: Kumari, Rajni, et al.
Publicado: (2019)

Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
por: Singh, Charandeep, et al.
Publicado: (2020)

Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension
por: Valuparampil Varghese, Mathews, et al.
Publicado: (2020)

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis
por: Ryuge, Akihiro, et al.
Publicado: (2021)

Catechin and Procyanidin B(2) Modulate the Expression of Tight Junction Proteins but Do Not Protect from Inflammation-Induced Changes in Permeability in Human Intestinal Cell Monolayers
por: Bianchi, Massimiliano G., et al.
Publicado: (2019)

The TLR4/NFκB-Dependent Inflammatory Response Activated by LPS Is Inhibited in Human Macrophages Pre-Exposed to Amorphous Silica Nanoparticles
por: Bianchi, Massimiliano G., et al.
Publicado: (2022)

Pyrogenic and Precipitated Amorphous Silica Nanoparticles Differentially Affect Cell Responses to LPS in Human Macrophages
por: G. Bianchi, Massimiliano, et al.
Publicado: (2020)

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism
por: Perry, Rachel J., et al.
Publicado: (2016)

Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas
por: Martins, Filipa, et al.
Publicado: (2020)

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells
por: Sant’Anna-Silva, Ana Carolina B., et al.
Publicado: (2021)

Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma
por: Khadka, Sunada, et al.
Publicado: (2021)

γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity
por: Corti, Alessandro, et al.
Publicado: (2019)

Comparative in Vitro Cytotoxicity of Realistic Doses of Benchmark Multi-Walled Carbon Nanotubes towards Macrophages and Airway Epithelial Cells
por: Di Cristo, Luisana, et al.
Publicado: (2019)

The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows
por: White, Heather M.
Publicado: (2015)

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
por: Muir, Alexander, et al.
Publicado: (2017)

Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability
por: Chiu, Martina, et al.
Publicado: (2020)

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
por: Rattigan, Kevin M, et al.
Publicado: (2023)

Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition
por: Jeong, Seung Min, et al.
Publicado: (2016)

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine
por: Cetinbas, Naniye Mallı, et al.
Publicado: (2016)

The Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia
por: Dander, Erica, et al.
Publicado: (2021)

Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function
por: Avellino, Giulia, et al.
Publicado: (2023)

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion
por: Stark, Romana, et al.
Publicado: (2009)

Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells
por: Scutera, Sara, et al.
Publicado: (2018)

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
por: Singleton, Dean C., et al.
Publicado: (2020)

In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells
por: Gonsalves, Wilson I., et al.
Publicado: (2020)

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
por: Kremer, Jeff Charles, et al.
Publicado: (2017)

Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress
por: Moon, Sun Jin, et al.
Publicado: (2020)

Improving the metabolic fidelity of cancer models with a physiological cell culture medium
por: Vande Voorde, Johan, et al.
Publicado: (2019)

Mesenchymal Stromal Cells Do Not Increase the Risk of Viral Reactivation Nor the Severity of Viral Events in Recipients of Allogeneic Stem Cell Transplantation
por: Lucchini, Giovanna, et al.
Publicado: (2012)

Hepatic glutamine synthetase controls N(5)-methylglutamine in homeostasis and cancer
por: Villar, Victor H., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ukuigepbigu18773j633qrqjgb