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Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways

Mevalonate 3,5-bisphosphate decarboxylase is involved in the recently discovered Thermoplasma-type mevalonate pathway. The enzyme catalyzes the elimination of the 3-phosphate group from mevalonate 3,5-bisphosphate as well as concomitant decarboxylation of the substrate. This entire reaction of the e...

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Detalles Bibliográficos
Autores principales: Aoki, Mizuki, Vinokur, Jeffrey, Motoyama, Kento, Ishikawa, Rino, Collazo, Michael, Cascio, Duilio, Sawaya, Michael R., Ito, Tomokazu, Bowie, James U., Hemmi, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254496/
https://www.ncbi.nlm.nih.gov/pubmed/35690147
http://dx.doi.org/10.1016/j.jbc.2022.102111