Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism

HDMX and its homologue HDM2 are two essential proteins for the cell; after genotoxic stress, both are phosphorylated near to their RING domain, specifically at serine 403 and 395, respectively. Once phosphorylated, both can bind the p53 mRNA and enhance its translation; however, both recognize p53 p...

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Detalles Bibliográficos
Autores principales: Calderon-González, Karla Gisel, Medina-Medina, Ixaura, Haronikova, Lucia, Hernychova, Lenka, Bonczek, Ondrej, Uhrik, Lukas, Hrabal, Vaclav, Vojtesek, Borivoj, Fahraeus, Robin, Hernández-Monge, Jesús, Olivares-Illana, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254666/
https://www.ncbi.nlm.nih.gov/pubmed/35674210
http://dx.doi.org/10.1042/BSR20220186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254666/
https://www.ncbi.nlm.nih.gov/pubmed/35674210
http://dx.doi.org/10.1042/BSR20220186

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