Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybrids

1,3,4-Thiadiazole analogues 3 and 4 were synthesised via the reaction of 1-(5-methyl-1-(5-(methylthio)-1,3,4-thiadiazol-2-yl)-1H-1,2,3-triazol-4-yl)ethan-1one 2 with vanillin or thiophene-2-carboxaldhyde, respectively through chalcone reaction. Compounds 3 and 4 were submitted to react with thiosemi...

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Detalles Bibliográficos
Autores principales: Rashdan, H.R.M., Abdelmonsef, A.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255848/
https://www.ncbi.nlm.nih.gov/pubmed/35818577
http://dx.doi.org/10.1016/j.molstruc.2022.133659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255848/
https://www.ncbi.nlm.nih.gov/pubmed/35818577
http://dx.doi.org/10.1016/j.molstruc.2022.133659

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