Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors

CD1a is a monomorphic antigen-presenting molecule on dendritic cells that presents lipids to αβ T cells. Whether CD1a represents a ligand for other immune receptors remains unknown. Here we use CD1a tetramers to show that CD1a is a ligand for Vδ1(+) γδ T cells. Functional studies suggest that two γδ...

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Detalles Bibliográficos
Autores principales: Wegrecki, Marcin, Ocampo, Tonatiuh A., Gunasinghe, Sachith D., von Borstel, Anouk, Tin, Shin Yi, Reijneveld, Josephine F., Cao, Thinh-Phat, Gully, Benjamin S., Le Nours, Jérôme, Moody, D. Branch, Van Rhijn, Ildiko, Rossjohn, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256601/
https://www.ncbi.nlm.nih.gov/pubmed/35790773
http://dx.doi.org/10.1038/s41467-022-31443-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256601/
https://www.ncbi.nlm.nih.gov/pubmed/35790773
http://dx.doi.org/10.1038/s41467-022-31443-9

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