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Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans
Genome-wide association studies (GWAS) in admixed populations such as African Americans (AA) have limited sample sizes, resulting in poor performance of polygenic risk scores (PRS). Based on the observations that many disease-causing genes are shared between AA and European ancestry (EA) populations...
Autores principales: | Lai, Dongbing, Schwantes-An, Tae-Hwi, Abreu, Marco, Chan, Grace, Hesselbrock, Victor, Kamarajan, Chella, Liu, Yunlong, Meyers, Jacquelyn L., Nurnberger, John I., Plawecki, Martin H., Wetherill, Leah, Schuckit, Marc, Zhang, Pengyue, Edenberg, Howard J., Porjesz, Bernice, Agrawal, Arpana, Foroud, Tatiana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256707/ https://www.ncbi.nlm.nih.gov/pubmed/35790736 http://dx.doi.org/10.1038/s41398-022-02029-2 |
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