Delineating the RAS Conformational Landscape

Mutations in RAS isoforms (KRAS, NRAS, and HRAS) are among the most frequent oncogenic alterations in many cancers, making these proteins high priority therapeutic targets. Effectively targeting RAS isoforms requires an exact understanding of their active, inactive, and druggable conformations. Howe...

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Detalles Bibliográficos
Autores principales: Parker, Mitchell I., Meyer, Joshua E., Golemis, Erica A., Dunbrack,, Roland L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Convergence and Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256797/
https://www.ncbi.nlm.nih.gov/pubmed/35536216
http://dx.doi.org/10.1158/0008-5472.CAN-22-0804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256797/
https://www.ncbi.nlm.nih.gov/pubmed/35536216
http://dx.doi.org/10.1158/0008-5472.CAN-22-0804

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