Cargando…

Modeling Human Cardiac Thin Filament Structures

Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments. Tropomyosin/troponin sterically blocks myosin-binding at low-calcium concentrations but moves t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rynkiewicz, Michael J., Pavadai, Elumalai, Lehman, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257132/ https://www.ncbi.nlm.nih.gov/pubmed/35812320 http://dx.doi.org/10.3389/fphys.2022.932333

Ejemplares similares

Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle
por: Lehman, William, et al.
Publicado: (2023)

Tropomyosin diffusion over actin subunits facilitates thin filament assembly
por: Fischer, Stefan, et al.
Publicado: (2016)

The mechanism of thin filament regulation: Models in conflict?
por: Geeves, Michael A., et al.
Publicado: (2019)

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy
por: Viswanathan, Meera C., et al.
Publicado: (2020)

Thermal Activation of Thin Filaments in Striated Muscle
por: Ishii, Shuya, et al.
Publicado: (2020)

Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers
por: López-Dávila, Alfredo Jesus, et al.
Publicado: (2020)

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation
por: Doran, Matthew H., et al.
Publicado: (2022)

Titin isoform size is not correlated with thin filament length in rat skeletal muscle
por: Greaser, Marion L., et al.
Publicado: (2014)

Alterations in thin filament length during postnatal skeletal muscle development and aging in mice
por: Gokhin, David S., et al.
Publicado: (2014)

A cylindrical assembly model and dynamics of the Ebola virus VP40 structural matrix
por: Pavadai, Elumalai, et al.
Publicado: (2018)

Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling
por: Sewanan, Lorenzo R., et al.
Publicado: (2016)

Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery
por: Lubomirov, Lubomir T., et al.
Publicado: (2023)

Cardiac muscle thin filament structures reveal calcium regulatory mechanism
por: Yamada, Yurika, et al.
Publicado: (2020)

The adipokinetic hormones and their cognate receptor from the desert locust, Schistocerca gregaria: solution structure of endogenous peptides and models of their binding to the receptor
por: Jackson, Graham E., et al.
Publicado: (2019)

Structure and Orientation of Troponin in the Thin Filament
por: Paul, Danielle M., et al.
Publicado: (2009)

Cardiac thin filament regulation and the Frank–Starling mechanism
por: Kobirumaki-Shimozawa, Fuyu, et al.
Publicado: (2014)

Microscopic heat pulses activate cardiac thin filaments
por: Ishii, Shuya, et al.
Publicado: (2019)

Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio
por: Bradshaw, Marston, et al.
Publicado: (2023)

The Sliding Filament Model: 1972–2004
por: Cooke, Roger
Publicado: (2004)

Force Measurements From Myofibril to Filament
por: Marston, Steven
Publicado: (2022)

The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes
por: Mudry, Ryan E., et al.
Publicado: (2003)

Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task
por: Piazzesi, Gabriella, et al.
Publicado: (2018)

Role of Active Contraction and Tropomodulins in Regulating Actin Filament Length and Sarcomere Structure in Developing Zebrafish Skeletal Muscle
por: Mazelet, Lise, et al.
Publicado: (2016)

Determination of the Maximum Velocity of Filaments in the in vitro Motility Assay
por: Bopp, Nasrin, et al.
Publicado: (2019)

New Insights on Bone Tissue and Structural Muscle-Bone Unit in Constitutional Thinness
por: Bailly, Mélina, et al.
Publicado: (2022)

Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography
por: Burgoyne, Thomas, et al.
Publicado: (2008)

Molecular Dynamics Assessment of Mechanical Properties of the Thin Filaments in Cardiac Muscle
por: Koubassova, Natalia A., et al.
Publicado: (2023)

High-resolution cryo-EM structure of the junction region of the native cardiac thin filament in relaxed state
por: Risi, Cristina M, et al.
Publicado: (2022)

Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts
por: Hanft, Laurin M., et al.
Publicado: (2023)

Humans Vary, So Cardiac Models Should Account for That Too!
por: Wiśniowska, Barbara, et al.
Publicado: (2017)

The opportunities and challenges of using Drosophila to model human cardiac diseases
por: Zhao, Yunpo, et al.
Publicado: (2023)

Integrative Structural Modelling of the Cardiac Thin Filament: Energetics at the Interface and Conservation Patterns Reveal a Spotlight on Period 2 of Tropomyosin
por: Margaret Sunitha, S, et al.
Publicado: (2012)

Role of Mitochondrial Retrograde Pathway in Regulating Ethanol-Inducible Filamentous Growth in Yeast
por: González, Beatriz, et al.
Publicado: (2017)

In-silico identification of the vaccine candidate epitopes against the Lassa virus hemorrhagic fever
por: Baral, Prabin, et al.
Publicado: (2020)

Data for the homology modelling of the red pigment-concentrating hormone receptor (Dappu-RPCHR) of the crustacean Daphnia pulex, and docking of its cognate agonist (Dappu-RPCH)
por: Jackson, Graham E., et al.
Publicado: (2017)

Novel insights into sarcomere regulatory systems control of cardiac thin filament activation
por: Solís, Christopher, et al.
Publicado: (2021)

Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament
por: Mason, Allison B., et al.
Publicado: (2021)

Vimentin Intermediate Filament Rings Deform the Nucleus During the First Steps of Adhesion
por: Terriac, Emmanuel, et al.
Publicado: (2019)

Human in vitro assay for irreversible electroporation cardiac ablation
por: Casciola, Maura, et al.
Publicado: (2023)

S-Net: a multiple cross aggregation convolutional architecture for automatic segmentation of small/thin structures for cardiovascular applications
por: Mu, Nan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d5rtjc6ts5g80b034mdqi84k1v