eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury

Background: Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologic that neutralizes the TLR4 ligand and DAMP, eNAMPT (extracel...

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Detalles Bibliográficos
Autores principales: Sammani, Saad, Bermudez, Tadeo, Kempf, Carrie L., Song, Jin H., Fleming, Justin C, Reyes Hernon, Vivian, Hufford, Matthew, Tang, Lin, Cai, Hua, Camp, Sara M., Natarajan, Viswanathan, Jacobson, Jeffrey R., Dudek, Steven M., Martin, Diego R., Karmonik, Christof, Sun, Xiaoguang, Sun, Belinda, Casanova, Nancy G., Bime, Christian, Garcia, Joe G. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257134/
https://www.ncbi.nlm.nih.gov/pubmed/35812318
http://dx.doi.org/10.3389/fphys.2022.916159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257134/
https://www.ncbi.nlm.nih.gov/pubmed/35812318
http://dx.doi.org/10.3389/fphys.2022.916159

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