Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysis

Our laboratory focuses on the development of novel neuroprotective cationic peptides, such poly-arginine-18 (R18: 18-mer of l-arginine; net charge +18) and its d-enantiomer R18D in stroke and other brain injuries. In the clinical development of R18/R18D, their cationic property raises potential safe...

Descripción completa

Detalles Bibliográficos
Autores principales: Edwards, Adam B., Mastaglia, Frank L., Knuckey, Neville W., Yip, Kwok-Ho, Meloni, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257347/
https://www.ncbi.nlm.nih.gov/pubmed/35812346
http://dx.doi.org/10.1016/j.bbrep.2022.101305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257347/
https://www.ncbi.nlm.nih.gov/pubmed/35812346
http://dx.doi.org/10.1016/j.bbrep.2022.101305

Ejemplares similares