High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP

Deoxynucleoside triphosphate (dNTP) triphosphohydrolases (dNTPases) are important enzymes that may perform multiple functions in the cell, including regulating the dNTP pools and contributing to innate immunity against viruses. Among the homologs that are best studied are human sterile alpha motif a...

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Detalles Bibliográficos
Autores principales: Klemm, Bradley P., Sikkema, Andrew P., Hsu, Allen L., Horng, James C., Hall, Traci M. Tanaka, Borgnia, Mario J., Schaaper, Roel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257424/
https://www.ncbi.nlm.nih.gov/pubmed/35643313
http://dx.doi.org/10.1016/j.jbc.2022.102073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257424/
https://www.ncbi.nlm.nih.gov/pubmed/35643313
http://dx.doi.org/10.1016/j.jbc.2022.102073

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