Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake

Cyclic peptides that modulate protein–protein interactions can be valuable therapeutic candidates if they can be delivered intact to their target proteins in cells. Here we systematically compare the effects of different helix-inducing cyclization constraints on the capacity of a macrocyclic peptide...

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Detalles Bibliográficos
Autores principales: de Araujo, Aline D., Lim, Junxian, Wu, Kai-Chen, Hoang, Huy N., Nguyen, Huy T., Fairlie, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257625/
https://www.ncbi.nlm.nih.gov/pubmed/35866171
http://dx.doi.org/10.1039/d1cb00231g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257625/
https://www.ncbi.nlm.nih.gov/pubmed/35866171
http://dx.doi.org/10.1039/d1cb00231g

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