Metastable intermediate during hIAPP aggregation catalyzed by membranes as detected with 2D IR spectroscopy

The aggregation of human islet amyloid polypeptide (hIAPP) into amyloid fibrils involves formation of oligomeric intermediates that are thought to be the cytotoxic species responsible for β-cell dysfunction in type 2 diabetes. hIAPP oligomers permeating or disrupting the cellular membrane may be one...

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Detalles Bibliográficos
Autores principales: Dicke, Sidney S., Maj, Michał, Fields, Caitlyn R., Zanni, Martin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257649/
https://www.ncbi.nlm.nih.gov/pubmed/35866164
http://dx.doi.org/10.1039/d2cb00028h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257649/
https://www.ncbi.nlm.nih.gov/pubmed/35866164
http://dx.doi.org/10.1039/d2cb00028h

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