“Human and Mouse Cross-Reactive” Albumin-Binding Helix–Loop–Helix Peptide Tag for Prolonged Bioactivity of Therapeutic Proteins

[Image: see text] The effectiveness of protein and peptide pharmaceuticals depends essentially on their intrinsic pharmacokinetics. Small-sized pharmaceuticals in particular often suffer from short serum half-lives due to rapid renal clearance. To improve the pharmacokinetics by association with ser...

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Detalles Bibliográficos
Autores principales: Nakatani, Yuto, Ye, Zhengmao, Ishizue, Yuki, Higashi, Taishi, Imai, Teruko, Fujii, Ikuo, Michigami, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257745/
https://www.ncbi.nlm.nih.gov/pubmed/35635006
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257745/
https://www.ncbi.nlm.nih.gov/pubmed/35635006
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00106

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