Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosis. However, the precise mechanisms of complement-mediated syn...

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Detalles Bibliográficos
Autores principales: Carpanini, Sarah M., Torvell, Megan, Bevan, Ryan J., Byrne, Robert A. J., Daskoulidou, Nikoleta, Saito, Takashi, Saido, Takaomi C., Taylor, Philip R., Hughes, Timothy R., Zelek, Wioleta M., Morgan, B. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258209/
https://www.ncbi.nlm.nih.gov/pubmed/35794654
http://dx.doi.org/10.1186/s40478-022-01404-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258209/
https://www.ncbi.nlm.nih.gov/pubmed/35794654
http://dx.doi.org/10.1186/s40478-022-01404-w

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