Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here we used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein...

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Detalles Bibliográficos
Autores principales: Hunt, Andrew C., Case, James Brett, Park, Young-Jun, Cao, Longxing, Wu, Kejia, Walls, Alexandra C., Liu, Zhuoming, Bowen, John E., Yeh, Hsien-Wei, Saini, Shally, Helms, Louisa, Zhao, Yan Ting, Hsiang, Tien-Ying, Starr, Tyler N., Goreshnik, Inna, Kozodoy, Lisa, Carter, Lauren, Ravichandran, Rashmi, Green, Lydia B., Matochko, Wadim L., Thomson, Christy A., Vögeli, Bastian, Krüger, Antje, VanBlargan, Laura A., Chen, Rita E., Ying, Baoling, Bailey, Adam L., Kafai, Natasha M., Boyken, Scott E., Ljubetič, Ajasja, Edman, Natasha, Ueda, George, Chow, Cameron M., Johnson, Max, Addetia, Amin, Navarro, Mary Jane, Panpradist, Nuttada, Gale, Michael, Freedman, Benjamin S., Bloom, Jesse D., Ruohola-Baker, Hannele, Whelan, Sean P. J., Stewart, Lance, Diamond, Michael S., Veesler, David, Jewett, Michael C., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258422/
https://www.ncbi.nlm.nih.gov/pubmed/35412328
http://dx.doi.org/10.1126/scitranslmed.abn1252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258422/
https://www.ncbi.nlm.nih.gov/pubmed/35412328
http://dx.doi.org/10.1126/scitranslmed.abn1252

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