Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and ex vivo photodynamic therapy

OBJECTIVE: Activated synovial fibroblasts are key effector cells in RA. Selectively depleting these based upon their expression of fibroblast activation protein (FAP) is an attractive therapeutic approach. Here we introduce FAP imaging of inflamed joints using (68)Ga-FAPI-04 in a RA patient, and aim...

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Detalles Bibliográficos
Autores principales: Dorst, Daphne N, Rijpkema, Mark, Buitinga, Mijke, Walgreen, Birgitte, Helsen, Monique M A, Brennan, Evan, Klein, Christian, Laverman, Peter, Ramming, Andreas, Schmidkonz, Christian, Kuwert, Torsten, Schett, Georg, van der Kraan, Peter M, Gotthardt, Martin, Koenders, Marije I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258553/
https://www.ncbi.nlm.nih.gov/pubmed/34450633
http://dx.doi.org/10.1093/rheumatology/keab664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258553/
https://www.ncbi.nlm.nih.gov/pubmed/34450633
http://dx.doi.org/10.1093/rheumatology/keab664

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