Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis

The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca(2+)-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1, Syt2, Syt9), SNAP-2...

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Detalles Bibliográficos
Autores principales: Lai, Ying, Tuvim, Michael J., Leitz, Jeremy, Peters, John, Pfuetzner, Richard A., Esquivies, Luis, Zhou, Qiangjun, Czako, Barbara, Cross, Jason B., Jones, Philip, Dickey, Burton F., Brunger, Axel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258623/
https://www.ncbi.nlm.nih.gov/pubmed/35814209
http://dx.doi.org/10.3389/fphar.2022.891041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258623/
https://www.ncbi.nlm.nih.gov/pubmed/35814209
http://dx.doi.org/10.3389/fphar.2022.891041

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