Mechanisms of 8‐aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model

Primaquine (PQ) and Tafenoquine (TQ) are clinically important 8‐aminoquinolines (8‐AQ) used for radical cure treatment of P. vivax infection, known to target hepatic hypnozoites. 8‐AQs can trigger haemolytic anaemia in individuals with glucose‐6‐phosphate dehydrogenase deficiency (G6PDd), yet the me...

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Detalles Bibliográficos
Autores principales: Flaherty, Siobhan, Strauch, Pamela, Maktabi, Mahdi, Pybus, Brandon S., Reichard, Gregory, Walker, Larry A, Rochford, Rosemary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258708/
https://www.ncbi.nlm.nih.gov/pubmed/35665597
http://dx.doi.org/10.1111/jcmm.17362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258708/
https://www.ncbi.nlm.nih.gov/pubmed/35665597
http://dx.doi.org/10.1111/jcmm.17362

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