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Computational design of a sensitive, selective phase-changing sensor protein for the VX nerve agent

The VX nerve agent is one of the deadliest chemical warfare agents. Specific, sensitive, real-time detection methods for this neurotoxin have not been reported. The creation of proteins that use biological recognition to fulfill these requirements using directed evolution or library screening method...

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Detalles Bibliográficos
Autores principales: McCann, James J., Pike, Douglas H., Brown, Mia C., Crouse, David T., Nanda, Vikas, Koder, Ronald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258810/
https://www.ncbi.nlm.nih.gov/pubmed/35857443
http://dx.doi.org/10.1126/sciadv.abh3421