Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression

Depletion of circulating asparagine with l-asparaginase (ASNase) is a mainstay of leukemia treatment and is under investigation in many cancers. Expression levels of asparagine synthetase (ASNS), which catalyzes asparagine synthesis, were considered predictive of cancer cell sensitivity to ASNase tr...

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Detalles Bibliográficos
Autores principales: Grima-Reyes, Manuel, Vandenberghe, Ashaina, Nemazanyy, Ivan, Meola, Pauline, Paul, Rachel, Reverso-Meinietti, Julie, Martinez-Turtos, Adriana, Nottet, Nicolas, Chan, Wai-Kin, Lorenzi, Philip L., Marchetti, Sandrine, Ricci, Jean-Ehrland, Chiche, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258813/
https://www.ncbi.nlm.nih.gov/pubmed/35857457
http://dx.doi.org/10.1126/sciadv.abn6491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258813/
https://www.ncbi.nlm.nih.gov/pubmed/35857457
http://dx.doi.org/10.1126/sciadv.abn6491

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