Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner

In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous...

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Detalles Bibliográficos
Autores principales: Brites, Pedro, Sousa, Monica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258894/
https://www.ncbi.nlm.nih.gov/pubmed/35793314
http://dx.doi.org/10.1371/journal.pbio.3001706
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author Brites, Pedro
Sousa, Monica M.
author_facet Brites, Pedro
Sousa, Monica M.
author_sort Brites, Pedro
collection PubMed
description In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
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spelling pubmed-92588942022-07-07 Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner Brites, Pedro Sousa, Monica M. PLoS Biol Primer In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder. Public Library of Science 2022-07-06 /pmc/articles/PMC9258894/ /pubmed/35793314 http://dx.doi.org/10.1371/journal.pbio.3001706 Text en © 2022 Brites, Sousa https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Brites, Pedro
Sousa, Monica M.
Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
title Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
title_full Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
title_fullStr Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
title_full_unstemmed Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
title_short Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
title_sort neurons contribute to pathology in a mouse model of krabbe disease in a cell-autonomous manner
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258894/
https://www.ncbi.nlm.nih.gov/pubmed/35793314
http://dx.doi.org/10.1371/journal.pbio.3001706
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AT sousamonicam neuronscontributetopathologyinamousemodelofkrabbediseaseinacellautonomousmanner

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