Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery. Current approaches for PD studies, including the analysis of novel kidney disease targeting therapeutic agents, are limited to animal models with unclear translatability to the human condition. To address this cha...

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Detalles Bibliográficos
Autores principales: Westerling-Bui, Amy D., Fast, Eva Maria, Soare, Thomas W., Venkatachalan, Srinivasan, DeRan, Michael, Fanelli, Alyssa B., Kyrychenko, Sergii, Hoang, Hien, Corriea, Grinal M., Zhang, Wei, Yu, Maolin, Daniels, Matthew, Malojcic, Goran, Pan-Zhou, Xin-Ru, Ledeboer, Mark W., Harmange, Jean-Christophe, Emani, Maheswarareddy, Tibbitts, Thomas T., Reilly, John F., Mundel, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258952/
https://www.ncbi.nlm.nih.gov/pubmed/35857479
http://dx.doi.org/10.1126/sciadv.abj5633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258952/
https://www.ncbi.nlm.nih.gov/pubmed/35857479
http://dx.doi.org/10.1126/sciadv.abj5633

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