Alzheimer’s disease: Ablating single master site abolishes tau hyperphosphorylation

Hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative tauopathies such as Alzheimer’s disease. A central unanswered question is why tau becomes progressively hyperphosphorylated. Here, we show that tau phosphorylation is governed by interdependence— a mechanistic link b...

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Detalles Bibliográficos
Autores principales: Stefanoska, Kristie, Gajwani, Mehul, Tan, Amanda R. P., Ahel, Holly I., Asih, Prita R., Volkerling, Alexander, Poljak, Anne, Ittner, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258953/
https://www.ncbi.nlm.nih.gov/pubmed/35857446
http://dx.doi.org/10.1126/sciadv.abl8809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258953/
https://www.ncbi.nlm.nih.gov/pubmed/35857446
http://dx.doi.org/10.1126/sciadv.abl8809

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