Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization

BACKGROUND: Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue, expanding the neuronal damage. This period represents a therapeutic window to inhibit SD and so reduce...

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Detalles Bibliográficos
Autores principales: Andrew, R. David, Farkas, Eszter, Hartings, Jed A., Brennan, K. C., Herreras, Oscar, Müller, Michael, Kirov, Sergei. A., Ayata, Cenk, Ollen-Bittle, Nikita, Reiffurth, Clemens, Revah, Omer, Robertson, R. Meldrum, Dawson-Scully, Ken D., Ullah, Ghanim, Dreier, Jens P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Spreading Cortical Depolarization
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259542/
https://www.ncbi.nlm.nih.gov/pubmed/35194729
http://dx.doi.org/10.1007/s12028-021-01429-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259542/
https://www.ncbi.nlm.nih.gov/pubmed/35194729
http://dx.doi.org/10.1007/s12028-021-01429-4

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