A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin

Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli (EHEC), can cause fatal systemic complications. Recently, we identified a potent inhibitory peptide that binds to the catalytic A-subunit of Stx. Here, using biochemical structural analysis and X-ray crystallography, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe-Takahashi, Miho, Senda, Miki, Yoshino, Ryunosuke, Hibino, Masahiro, Hama, Shinichiro, Terada, Tohru, Shimizu, Kentaro, Senda, Toshiya, Nishikawa, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259562/
https://www.ncbi.nlm.nih.gov/pubmed/35794188
http://dx.doi.org/10.1038/s41598-022-15316-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259562/
https://www.ncbi.nlm.nih.gov/pubmed/35794188
http://dx.doi.org/10.1038/s41598-022-15316-1

Ejemplares similares