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A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin

Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli (EHEC), can cause fatal systemic complications. Recently, we identified a potent inhibitory peptide that binds to the catalytic A-subunit of Stx. Here, using biochemical structural analysis and X-ray crystallography, w...

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Detalles Bibliográficos
Autores principales:	Watanabe-Takahashi, Miho, Senda, Miki, Yoshino, Ryunosuke, Hibino, Masahiro, Hama, Shinichiro, Terada, Tohru, Shimizu, Kentaro, Senda, Toshiya, Nishikawa, Kiyotaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259562/ https://www.ncbi.nlm.nih.gov/pubmed/35794188 http://dx.doi.org/10.1038/s41598-022-15316-1

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