Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease

Perivascular spaces (PVS) drain brain waste metabolites, but their specific flow paths are debated. Meningeal pia mater reportedly forms the outermost boundary that confines flow around blood vessels. Yet, we show that pia is perforated and permissive to PVS fluid flow. Furthermore, we demonstrate t...

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Detalles Bibliográficos
Autores principales: Mestre, Humberto, Verma, Natasha, Greene, Thom D., Lin, LiJing A., Ladron-de-Guevara, Antonio, Sweeney, Amanda M., Liu, Guojun, Thomas, V. Kaye, Galloway, Chad A., de Mesy Bentley, Karen L., Nedergaard, Maiken, Mehta, Rupal I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259669/
https://www.ncbi.nlm.nih.gov/pubmed/35794106
http://dx.doi.org/10.1038/s41467-022-31257-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259669/
https://www.ncbi.nlm.nih.gov/pubmed/35794106
http://dx.doi.org/10.1038/s41467-022-31257-9

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